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Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities

24 Nov 2023

Abstract excerpt

BACKGROUND: Mitochondria-derived peptides (MDPs) represent a recently discovered family of peptides encoded by short open reading frames (ORFs) found within mitochondrial genes. This group includes notable members including humanin (HN), mitochondrial ORF of the 12S rDNA type-c (MOTS-c), and small humanin-like peptides 1-6 (SHLP1-6). MDPs assume pivotal roles in the regulation of diverse cellular processes,...

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PMID: 38008175
DOI: 10.1016/j.jare.2023.11.018

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