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Article

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

15 Sept 2022

Abstract excerpt

Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and druggability potential of the entire PCSK family for CVD. We applied an integrative approach, combining genetic, transcriptomic and proteomic data from three...

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PMID: 36188622
DOI: 10.3389/fphar.2022.988561

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