Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment

Abstract excerpt

Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)- based proteomics and peptidomics datasets. Here, we assessed literature-reported MS-based identifications of unannotated human proteins. We find that studies vary by three orders of magnitude in the number of unannotat...

Topics

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• Advanced Proteomics Techniques and Applications
• Machine Learning in Bioinformatics
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

3ee70546-2aef-5b91-ad14-272a22321dd1

DOI

10.1101/2025.02.19.639069