Expanding the human metaproteome: enhancing small open reading frame (smORF) prediction and ultra-deep detection of smORF-encoded proteins in the gut microbiome

Abstract excerpt

<title>Abstract</title> <p>Small open reading frames (smORFs), which encode proteins under 100 amino acids, represent an underexplored dimension of the human gut microbiome, despite growing evidence of their essential biological roles. Due to small size and poor annotation, smORFs are typically excluded from metagenomic/metaproteomic analyses. Here, we present a high-resolution multi-omic workflow that integrates...

Topics

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• Gut microbiota and health
• Metabolomics and Mass Spectrometry Studies
• Nutritional Studies and Diet

Identifiers and source

Literature Corpus work

d494bd7d-a79a-5d75-b169-97f147ca0398

DOI

10.21203/rs.3.rs-7768562/v1