Article

Tissue-specific downregulation of <i>EDTP</i> suppresses polyglutamine protein aggregates and extends lifespan in <i>Drosophila</i>

2017-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Drosophila egg-derived tyrosine phosphatase (EDTP, also called JUMPY) is a lipid phosphatase essential in oogenesis and muscle function in the adult stage. Although mammalian JUMPY negatively regulates autophagy, loss-of-JUMPY causes muscle dysfunction and is associated with a rare genetic disorder called centronuclear myopathy. Here we show that tissue-specific downregulation of EDTP in Drosop...

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Literature Corpus work: d58698e0-c483-5ee7-9c96-d123d3384a29
DOI: 10.1101/130559

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