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A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging

17 Dec 2022

Abstract excerpt

Ageing is driven by the progressive, lifelong accumulation of cellular damage. Autophagy (cellular self-eating) functions as a major cell clearance mechanism to degrade such damages, and its capacity declines with age. Despite its physiological and medical significance, it remains largely unknown why autophagy becomes incapable of effectively eliminating harmful cellular materials in many cells at advanced ages....

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PMID: 36528685
DOI: 10.1038/s41598-022-24843-w

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