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Juvenile and adult expression of polyglutamine expanded <i>huntingtin</i> produce distinct aggregate distributions in <i>Drosophila</i> muscle

2023-04-04

Abstract excerpt

<h4>ABSTRACT</h4> While Huntington’s disease (HD) is widely recognized as a disease affecting the nervous system, much evidence has accumulated to suggest peripheral or non-neuronal tissues are affected as well. Here, we utilize the UAS/GAL4 system to express a pathogenic HD construct in the muscle of the fly, and characterize the effects. We observe detrimental phenotypes such as reduced lifespan, decreased loco...

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Literature Corpus work
c9a6d8db-4968-575e-b364-20b221112df6
DOI
10.1101/2023.04.04.535619
Open publication

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Juvenile and adult expression of polyglutamine expanded <i>huntingtin</i> produce distinct aggregate distributions in <i>Drosophila</i> muscleDOI 10.1101/2023.04.04.535619
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