Article

Blocking cell fusion inhibits age-induced polyploidy and maintains epithelial organization in <i>Drosophila</i>

2021-08-09

Abstract excerpt

<h4>Summary</h4> A characteristic of normal aging and age-related diseases is the remodeling of a tissue’s cellular organization through polyploid cell growth. Polyploidy arises from an increase in nuclear ploidy or the number of nuclei per cell. However, it is not known whether age-induced polyploidy is an adaption to stressors or a precursor to degeneration. Here, we find that the adult fruit fly’s abdominal ep...

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Literature Corpus work: 244271b8-3f75-5c65-a9bf-e5e3ff0798e3
DOI: 10.1101/2021.08.09.455651

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