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Article

Inhibition of autophagy rescues muscle atrophy in a LGMDD2 Drosophila model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2021

Blázquez-Bernal Águeda, Fernandez-Costa Juan M, Bargiela Ariadna, Artero Ruben

Abstract excerpt

Limb-girdle muscular dystrophy D2 (LGMDD2) is an ultrarare autosomal dominant myopathy caused by mutation of the normal stop codon of the TNPO3 nuclear importin. The mutant protein carries a 15 amino acid C-terminal extension associated with pathogenicity. Here we report the first animal model of the disease by expressing the human mutant TNPO3 gene in Drosophila musculature or motor neurons and concomitantly...

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Identifiers

PMID: 34547132
DOI: 10.1096/fj.202100539RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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