Article

Insights into Dentatorubral-Pallidoluysian Atrophy from a new <i>Drosophila</i> model of disease

2024-12-10

Abstract excerpt

<h4>ABSTRACT</h4> Dentatorubral-pallidoluysian atrophy (DRPLA) is a neurodegenerative disorder that presents with ataxia, dementia and epilepsy. As a member of the polyglutamine family of diseases, DRPLA is caused by abnormal CAG triplet expansion beyond 48 repeats in the protein-coding region of ATROPHIN 1 ( ATN1 ), a transcriptional co-repressor. To better understand DRPLA, we generated new Drosophila lines...

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Literature Corpus work: f3c35361-7e0e-5a44-8bee-8a9675df47b9
DOI: 10.1101/2024.12.05.627083

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