Article

Parkinson mutations in <i>DNAJC6</i> cause lipid defects and neurodegeneration that are rescued by Synj1

2022-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Recent evidence links dysfunctional lipid metabolism to the pathogenesis of Parkinson’s disease, but the mechanisms are not resolved. Here, we created a new Drosophila knock-in model of DNAJC6/Auxilin and find that the pathogenic mutation causes synaptic dysfunction, neurological defects and neurodegeneration, as well as specific lipid metabolism alterations. In these mutants membrane lipids c...

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Literature Corpus work: 53c3e4c3-6b72-5928-9c8c-ac930511cdd2
DOI: 10.1101/2022.04.27.489745

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