Article
Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability.
Molecular psychiatry - 1 Nov 2012
Nguyen L S, Jolly L, Shoubridge C, Chan W K, Huang L, Laumonnier F, Raynaud M, Hackett A, Field M, Rodriguez J, Srivastava A K, Lee Y, Long R, Addington A M, Rapoport J L, Suren S, Hahn C N, Gamble J, Wilkinson M F, Corbett M A, Gecz J
Abstract excerpt
The nonsense-mediated mRNA decay (NMD) pathway was originally discovered by virtue of its ability to rapidly degrade aberrant mRNAs with premature termination codons. More recently, it was shown that NMD also directly regulates subsets of normal transcripts, suggesting that NMD has roles in normal biological processes. Indeed, several NMD factors have been shown to regulate neurological events (for example,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.