Article

Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis

2025-10-27

Abstract excerpt

<h4>ABSTRACT</h4> The contribution of somatic gene dosage mutations (CNA) to breast cancer metastasis remains poorly defined. Using 9 transplantable human neoadjuvant-naive triple-negative breast cancer xenografts, we studied the fitness of copy number clones in spontaneous metastasis from orthotopic transplant sites. Metastatic site preference was strongly patient-dependent, and the emergence of metastases exhib...

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Literature Corpus work: d54bc023-8d93-5c51-92c4-03defbbcbab7
DOI: 10.1101/2025.10.27.684911

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