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Article

Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts.

Oncogene - 1 Jan 2022

Kuiken Hendrik J, Dhakal Sabin, Selfors Laura M, Friend Chandler M, Zhang Tian, Callari Maurizio, Schackmann Ron C J, Gray G Kenneth, Crowdis Jett, Bhang Hyo-Eun C, Baslan Timour, Stegmeier Frank, Gygi Steven P, Caldas Carlos, Brugge Joan S

Abstract excerpt

Intratumoral heterogeneity has been described for various tumor types and models of human cancer, and can have profound effects on tumor progression and drug resistance. This study describes an in-depth analysis of molecular and functional heterogeneity among subclonal populations (SCPs) derived from a single triple-negative breast cancer cell line, including copy number analysis, whole-exome and RNA sequencing,...

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Identifiers

PMID: 34703030
DOI: 10.1038/s41388-021-02075-y
PMCID: PMC8727509

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