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Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones

1 May 2025

Abstract excerpt

Clonal fitness and plasticity drive cancer heterogeneity. We used expressed lentiviral-based cellular barcodes combined with single-cell RNA sequencing to associate single-cell profiles with in vivo clonal growth. This generated a significant resource of growth measurements from over 20,000 single-cell-derived clones in 110 xenografts from 26 patient-derived breast cancer xenograft models. 167,375 single-cell RNA...

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PMID: 40359107
DOI: 10.1016/j.celrep.2025.115699

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