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Article

Treatment Represents a Key Driver of Metastatic Cancer Evolution.

Cancer research - 16 Aug 2022

Christensen Ditte S, Ahrenfeldt Johanne, Sokač Mateo, Kisistók Judit, Thomsen Martin K, Maretty Lasse, McGranahan Nicholas, Birkbak Nicolai J

Abstract excerpt

Metastasis is the main cause of cancer death, yet the evolutionary processes behind it remain largely unknown. Here, through analysis of large panel-based genomic datasets from the AACR Genomics Evidence Neoplasia Information Exchange project, including 40,979 primary and metastatic tumors across 25 distinct cancer types, we explore how the evolutionary pressure of cancer metastasis shapes the selection of...

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PMID: 35731928
DOI: 10.1158/0008-5472.CAN-22-0562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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