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Article

Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers

18 Jul 2024

Abstract excerpt

BACKGROUND: The encoding of cell intrinsic drug resistance states in breast cancer reflects the contributions of genomic and non-genomic variations and requires accurate estimation of clonal fitness from co-measurement of transcriptomic and genomic data. Somatic copy number (CN) variation is the dominant mutational mechanism leading to transcriptional variation and notably contributes to platinum chemotherapy...

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PMID: 39026273
DOI: 10.1186/s13059-024-03318-3

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