Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases.

PLoS medicine - 1 Dec 2016

Hoadley Katherine A, Siegel Marni B, Kanchi Krishna L, Miller Christopher A, Ding Li, Zhao Wei, He Xiaping, Parker Joel S, Wendl Michael C, Fulton Robert S, Demeter Ryan T, Wilson Richard K, Carey Lisa A, Perou Charles M, Mardis Elaine R

Abstract excerpt

BACKGROUND: Metastasis is the main cause of cancer patient deaths and remains a poorly characterized process. It is still unclear when in tumor progression the ability to metastasize arises and whether this ability is inherent to the primary tumor or is acquired well after primary tumor formation. Next-generation sequencing and analytical methods to define clonal heterogeneity provide a means for identifying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Breast Cancer Treatment Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Cancer Diagnosis and Treatment

Share to Disease Progression

Share to Genomics

Share to Multiple and Secondary Primary Cancers

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 27923045
DOI: 10.1371/journal.pmed.1002174
PMCID: PMC5140046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases.PMID 27923045Read ↗

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer.Semantic proximity Read ↗

Mutational profiles of breast cancer metastases from a rapid autopsy series reveal multiple evolutionary trajectories.Semantic proximity Read ↗

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastasesSemantic proximity Read ↗

Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations.Semantic proximity Read ↗

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases.Semantic proximity Read ↗

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancerSemantic proximity Read ↗

Genomic Analyses of Breast Cancer Progression Reveal Distinct Routes of Metastasis Emergence.Semantic proximity Read ↗

Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases.Semantic proximity Read ↗

Novel temporal and spatial patterns of metastatic colonization from rapid-autopsy tumor biopsiesSemantic proximity Read ↗

Rare subclonal sequencing of breast cancers indicates putative metastatic driver mutations are predominately acquired after dissemination.Semantic proximity Read ↗

The Genetic Evolution of Metastasis.Semantic proximity Read ↗

Genomic Evolution of Breast Cancer Metastasis and Relapse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.