Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

15 Feb 2019

Abstract excerpt

Primary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting metastases are poorly understood. Here we use cellular barcoding of two treatment-naïve TNBC patient-derived xenografts (PDXs) to track the spatio-temporal fate of thousands of barcoded clones in primary tumors, and their metastases. Tumor resection had a major impact on reducing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Cell Image Analysis Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30770823
DOI: 10.1038/s41467-019-08595-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancerPMID 30770823Read ↗

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenograftsSemantic proximity Read ↗

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancerSemantic proximity Read ↗

Barcoding reveals complex clonal dynamics of de novo transformed human mammary cellsSemantic proximity Read ↗

Genetic barcoding uncovers the clonal makeup of solid and liquid biopsies and their ability to capture intra-tumoral heterogeneitySemantic proximity Read ↗

Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenograftsSemantic proximity Read ↗

Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatmentSemantic proximity Read ↗

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy responseSemantic proximity Read ↗

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clustersSemantic proximity Read ↗

SunCatcher: Clonal Barcoding with qPCR-Based Detection Enables Functional Analysis of Live Cells and Generation of Custom Combinations of Cells for Research and DiscoverySemantic proximity Read ↗

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapySemantic proximity Read ↗

Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts.Semantic proximity Read ↗

The breast cancer pro-metastatic phenotype requires concomitant hyper-activation of ECM remodeling and dsRNA-IFN1 signaling in rare clone cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.