Article
Genomic Analyses of Breast Cancer Progression Reveal Distinct Routes of Metastasis Emergence.
Scientific reports - 9 Mar 2017
Krøigård Anne Bruun, Larsen Martin Jakob, Brasch-Andersen Charlotte, Lænkholm Anne-Vibeke, Knoop Ann S, Jensen Jeanette Dupont, Bak Martin, Mollenhauer Jan, Thomassen Mads, Kruse Torben A
Abstract excerpt
A main controversy in cancer research is whether metastatic abilities are present in the most advanced clone of the primary tumor or result from independently acquired aberrations in early disseminated cancer cells as suggested by the linear and the parallel progression models, respectively. The genetic concordance between different steps of malignant progression is mostly unexplored as very few studies have...
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