Article

Brain xQTL map: Integrating the genetic architecture of the human brain transcriptome and epigenome

2017-05-27

Abstract excerpt

We perform quantitative trait locus (xQTL) analyses on a multi-omic dataset, comprising RNA sequence, DNA methylation, and histone acetylation ChIP sequence data from the dorsolateral prefrontal cortex of 411 older adult individuals. We identify SNPs that are significantly associated with gene expression, DNA methylation, and histone modification levels. Many SNPs influence more than one type of molecular feature,...

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Literature Corpus work: d540c673-791a-5f93-898e-8d6438bd4dee
DOI: 10.1101/142927

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