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Article

Molecular Quantitative Trait Locus Mapping in Human Complex Diseases.

Current protocols - 1 May 2022

Olayinka Oluwatosin A, O'Neill Nicholas K, Farrer Lindsay A, Wang Gao, Zhang Xiaoling

Abstract excerpt

Mapping quantitative trait loci (QTLs) for molecular traits from chromatin to metabolites (i.e., xQTLs) provides insight into the locations and effect modes of genetic variants that influence these molecular phenotypes and the propagation of functional consequences of each variant. xQTL studies indirectly interrogate the functional landscape of the molecular basis of complex diseases, including the impact of...

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Identifiers

PMID: 35587224
DOI: 10.1002/cpz1.426
PMCID: PMC9186089

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