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Article

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome.

Nature neuroscience - 1 Oct 2017

Ng Bernard, White Charles C, Klein Hans-Ulrich, Sieberts Solveig K, McCabe Cristin, Patrick Ellis, Xu Jishu, Yu Lei, Gaiteri Chris, Bennett David A, Mostafavi Sara, De Jager Philip L

Abstract excerpt

We report a multi-omic resource generated by applying quantitative trait locus (xQTL) analyses to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral prefrontal cortex of 411 older adults who have all three data types. We identify SNPs significantly associated with gene expression, DNA methylation and histone modification levels. Many of these SNPs influence multiple molecular...

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Identifiers

PMID: 28869584
DOI: 10.1038/nn.4632
PMCID: PMC5785926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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