Article

Distributional genetic effects reveal context-dependent molecular regulation in human brain aging and Alzheimer’s disease

2025-12-01

Abstract excerpt

<title>Abstract</title> <p> Molecular QTL studies quantify whether genetic variants affect molecular traits, but non-linear effects including distributional patterns, variance, and interactions provide mechanistic insights beyond mean-level associations. Methods for detecting distributional effects have been developed for eQTL analysis, yet applications have focused on method demonstrations rather than large-sca...

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Literature Corpus work: 0edbb837-d2fd-5ce8-9b22-f9d0791e46ce
DOI: 10.21203/rs.3.rs-8219833/v1

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