Article

Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitise MRSA to β-lactam antibiotics

2022-09-03

Abstract excerpt

Elucidating the complex mechanisms controlling mecA /PBP2a-mediated β-lactam resistance in methicillin resistant Staphylococcus aureus (MRSA) has the potential to identify new drug targets with therapeutic potential. Here, we report that mutations that interfere with de novo purine synthesis ( pur operon), purine transport (NupG, PbuG and PbuX) and the nucleotide salvage pathway (DeoD2, Hpt) increased β-lactam...

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Literature Corpus work: d507d750-607b-5a0a-896e-037e5c99b8db
DOI: 10.1101/2022.09.01.506298

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