Back to search

Article

Purine and pyrimidine analogues differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin resistant <i>Staphylococcus aureus</i>

2026-05-25

Abstract excerpt

Maintaining the efficacy of β-lactam antibiotics against Staphylococcus aureus is a clinical priority given the prevalence of methicillin-resistant S. aureus (MRSA). We previously showed that the pyrimidine analogues 5-fluorouracil (5-FU) and 5-fluorouridine (5-FUrd) synergize with β-lactams. Here, we extended this by evaluating additional nucleotide metabolism-targeting agents. Gemcitabine (Gem) and mitomycin C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
77ed2992-a9da-5d6a-96ae-41cadebf1178
DOI
10.64898/2026.05.24.727567
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Purine and pyrimidine analogues differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin resistant <i>Staphylococcus aureus</i>DOI 10.64898/2026.05.24.727567
Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogrammingSemantic proximity
The anticancer chemotherapy drug 5-Fluorouracil has positive interaction with antibiotics and can select for antibiotic resistance in <i>Staphylococcus aureus</i>Semantic proximity
Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitise MRSA to β-lactam antibioticsSemantic proximity
Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related ProteinsSemantic proximity
Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureusSemantic proximity
Epigenetic modulator UVI5008 inhibits MRSA by interfering with bacterial gyraseSemantic proximity
Genomic Signatures and Functional Pathways Underlying 5-Fluorouracil Resistance in Head and Neck Cancer associated StreptococciSemantic proximity
Defining the roles of pyruvate oxidation, TCA cycle, and mannitol metabolism in methicillin resistance <i>Staphylococcus aureus</i> catheter-associated urinary tract infectionSemantic proximity
Synergistic Antibiotic Activity and Integrated Genomic–Metabolomic Profiling of Patch - and Plaque-Derived <i>Staphylococcus aureus</i> in Mycosis FungoidesSemantic proximity
Phage resistance impacts antibiotic susceptibility and virulence in <i>Staphylococcus aureus</i>Semantic proximity
Genomics and Antimicrobial Drug DiscoverySemantic proximity
Mechanisms of folate metabolism-related substances affecting Staphylococcus aureus infectionSemantic proximity
Select a neighboring publication to make it the new centre.