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Article

Guanine Limitation Results in CodY-Dependent and -Independent Alteration of Staphylococcus aureus Physiology and Gene Expression.

Journal of bacteriology - 15 Jul 2018

King Alyssa N, Borkar Samiksha A, Samuels David J, Batz Zachary, Bulock Logan L, Sadykov Marat R, Bayles Kenneth W, Brinsmade Shaun R

Abstract excerpt

In Staphylococcus aureus, the global transcriptional regulator CodY modulates the expression of hundreds of genes in response to the availability of GTP and the branched-chain amino acids isoleucine, leucine, and valine (ILV). CodY DNA-binding activity is high when GTP and ILV are abundant. When GTP and ILV are limited, CodY's affinity for DNA drops, altering expression of CodY-regulated targets. In this work, we...

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PMID: 29712876
DOI: 10.1128/JB.00136-18
PMCID: PMC6018361

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