New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus.

Abstract excerpt

Nucleotide signaling networks are key to facilitate alterations in gene expression, protein function, and enzyme activity in response to diverse stimuli. Cyclic di-adenosine monophosphate (c-di-AMP) is an important secondary messenger molecule produced by the human pathogen Staphylococcus aureus and is involved in regulating a number of physiological processes including potassium transport. S. aureus must ensure...

Topics

• Acids
• Bacterial Proteins
• Dinucleoside Phosphates
• Dipeptides
• Gene Expression Regulation, Bacterial
• Humans
• Hydrolysis
• Mutation
• Phosphoric Diester Hydrolases
• Second Messenger Systems