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The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in <i>Staphylococcus aureus</i>

16 Aug 2016

Abstract excerpt

Staphylococcus aureus is an important opportunistic human pathogen that is highly resistant to osmotic stresses. To survive an increase in osmolarity, bacteria immediately take up potassium ions and small organic compounds known as compatible solutes. The second messenger cyclic diadenosine monophosphate (c-di-AMP) reduces the ability of bacteria to withstand osmotic stress by binding to and inhibiting several...

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PMID: 27531650
DOI: 10.1126/scisignal.aaf7279

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