Article

Regulation of cancer epigenomes with a histone-binding synthetic transcription factor

2016-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin proteins have expanded the mammalian synthetic biology toolbox by enabling control of active and silenced states at endogenous genes. Others have reported synthetic proteins that bind DNA and regulate genes by altering chromatin marks, such as histone modifications. Previously we reported the first synthetic transcriptional activator, the "Polycomb-based transcription factor" (PcTF), t...

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Literature Corpus work: d4e50115-93b8-5113-9833-26dd4875c1e3
DOI: 10.1101/072975

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