Article

PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion

2023-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Scientists have used small molecule inhibitors and genetic knockdown of gene-silencing polycomb repressive complexes (PRC1/2) to determine if restoring the expression of tumor suppressor genes can block proliferation and invasion of cancer cells. A major limitation of this approach is that inhibitors can not restore key transcriptional activators that are mutated in many cancers, such as p53 and...

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Literature Corpus work: fbb30ca0-39af-51fc-8cbf-8b8705738422
DOI: 10.1101/2023.01.23.525196

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