Article
Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements.
Genes & development - 1 Nov 2013
Alfieri Claudio, Gambetta Maria Cristina, Matos Raquel, Glatt Sebastian, Sehr Peter, Fraterman Sven, Wilm Matthias, Müller Jürg, Müller Christoph W
Abstract excerpt
Polycomb group (PcG) protein complexes repress developmental regulator genes by modifying their chromatin. How different PcG proteins assemble into complexes and are recruited to their target genes is poorly understood. Here, we report the crystal structure of the core of the Drosophila PcG protein complex Pleiohomeotic (Pho)-repressive complex (PhoRC), which contains the Polycomb response element (PRE)-binding...
Topics
- Amino Acid Sequence
- Animals
- Chromosomal Proteins, Non-Histone
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Polycomb-Group Proteins
- Protein Binding