Article

A novel KRAS Exon 2 drop-off Digital PCR Assay for Mutation Detection in Cell- free DNA of Cancer Patients

2024-12-17

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold><italic> KRAS</italic> exon 2 mutations are highly prevalent in human malignancies, making them attractive targets for detection and monitoring in cell-free DNA (cfDNA) of cancer patients. Drop-off assays designed for digital polymerase chain reaction (ddPCR drop-off) span entire mutational hotspots and detect any mutated allele within the covered region, overcom...

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Literature Corpus work: d4ce9bb0-25ec-54d1-838e-9487d96dabc9
DOI: 10.21203/rs.3.rs-5418095/v1

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