Article
Single-nucleotide variant profiling in liquid biopsy with RECO-Cas.
Science advances - 22 May 2026
Guo Chong, Zhang Shuo, Yerramsetti Ramachandra, Zhang Jiongyu, Guan Xin, Yang Rui, Hou Chengyu, Pei Minjie, Schalper Kurt T, Liu Xingye, Li Ziyue, Perpetua Lorrie, Gan Wenqi, Ibrahim Omar, Clark Rachael A, Liu Changchun
Abstract excerpt
Mutation detection of cell-free DNA (cfDNA) through liquid biopsy is essential for precision oncology, resistance profiling, and informed clinical decision-making. However, its clinical application has remained limited by the lack of simple, rapid, accurate, and cost-effective detection approaches. Here, we report a recombined DNA construct-activated Cas12a (RECO-Cas) assay for profiling cfDNA mutations. The...
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