Article

Plasma proteins and onset of atherosclerosis: Integrating human plasma proteogenomics, transcriptomics and in vivo evidence

2025-05-07

Abstract excerpt

<title>Abstract</title> <p>Backgroud: Atherosclerosis, a leading driver of cardiovascular disease (CVD), lacks effective early therapeutic targets. Leveraging plasma proteome-wide Mendelian randomization (MR), this study identifies novel causal proteins implicated in atherosclerosis pathogenesis. <h4>Method:</h4> Genome-wide MR was conducted using cis-pQTLs from deCODE and UKB-PPP cohorts (approximately 90,000 in...

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Literature Corpus work: 6cc6d61b-736d-5bbf-8d12-a832e87603a1
DOI: 10.21203/rs.3.rs-6413545/v1

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