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Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases.

Cardiovascular diabetology - 1 Aug 2025

Wang Jia-Hao, Dong Shan-Shan, Huang Wei, Wang Hao-An, Liu Shao-Shan, Ma Xiaoyi, Zhu Ren-Jie, Shi Wei, Wu Hao, Yu Ke, Zhang Tian-Pei, Wang Cong-Ru, Guo Yan, Xue Hanzhong, Yang Tie-Lin

Abstract excerpt

BACKGROUND: Cardiovascular diseases (CVD) are the leading cause of global mortality, yet current treatments benefit only a subset of patients. To identify new potential treatment targets, we conducted the first proteome wide association study (PWAS) for 26 CVDs using plasma proteomics data from the largest cohort to date (53,022 individuals in the UK Biobank Pharma Proteomics Project (UKB-PPP)). METHODS AND...

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Identifiers

PMID: 40751156
DOI: 10.1186/s12933-025-02847-w
PMCID: PMC12317611

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