Article

Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration

2021-01-21

Abstract excerpt

A hallmark of Alzheimer’s disease is the aggregation of insoluble amyloid-beta plaques and tau protein neurofibrillary tangles. A key histopathological observation is that tau protein aggregates follow a structured progression pattern through the brain. Mathematical network models of prion-like propagation have the ability to capture such patterns but a number of factors impact the observed staging result, thus in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4b9f006-c22b-5024-9d95-753c5d591c94
DOI: 10.1101/2021.01.21.427609

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Braiding Braak and Braak: Staging patterns and model selection in network neurodegenerationDOI 10.1101/2021.01.21.427609Read

Modeling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosisSemantic proximity Read

Modelling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosisSemantic proximity Read

Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like <i>α</i> -synuclein propagationSemantic proximity Read

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s diseaseSemantic proximity Read

Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutationSemantic proximity Read

Gene-Modulated Network Diffusion for Improved Modeling of Amyloid- <i>β</i> Spread in Alzheimer’s DiseaseSemantic proximity Read

Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer’s diseaseSemantic proximity Read

Endogenous pathology in tauopathy mice progresses via brain networksSemantic proximity Read

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s diseaseSemantic proximity Read

A physics-based model explains the prion-like features of neurodegeneration in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosisSemantic proximity Read

Local vulnerability and global connectivity jointly shape neurodegenerative disease propagationSemantic proximity Read

Local vulnerability and global connectivity jointly shape neurodegenerative disease propagationSemantic proximity Read