Article

A physics-based model explains the prion-like features of neurodegeneration in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis

2018-10-15

Abstract excerpt

Prion disease is characterized by a chain reaction in which infectious misfolded proteins force native proteins into a similar pathogenic structure. Recent studies have reinforced the hypothesis that the prion paradigm–the templated growth and spreading of misfolded proteins–could help explain the progression of a variety of neurodegenerative disorders. However, our current understanding of prion-like growth and s...

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Literature Corpus work: 26dba4f1-3d2a-55a8-855f-3a1b0881b428
DOI: 10.1016/j.jmps.2018.10.013

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