Article

Modelling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis

2021-02-25

Abstract excerpt

The neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of upper and lower motor neurons, with pathological involvement of cerebral motor and, additionally, extra-motor areas, in a clinicopathological spectrum with frontotemporal dementia (FTD). A key unresolved question is whether the distribution of pathology in ALS is driven by molecular factors such as region...

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Literature Corpus work: c8bfc80b-a649-5766-9e3a-90cfbf920521
DOI: 10.1101/2021.02.24.431118

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