Article

Tau spreading is driven by neuronal connectivity in primary tauopathies - evidence from tau-PET and histopathology

2021-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies (4RT), including cortico-basal degeneration and progressive supranuclear palsy (PSP). Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4RTs, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here,...

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Literature Corpus work: 33c5b412-d447-561b-813e-80a8c8ebf725
DOI: 10.1101/2021.08.16.21261523

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