Haematopoietic stem cells require a highly regulated protein synthesis rate.

doi:10.1038/nature13035

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Article

Haematopoietic stem cells require a highly regulated protein synthesis rate.

Nature - 1 May 2014

Signer Robert A J, Magee Jeffrey A, Salic Adrian, Morrison Sean J

Abstract excerpt

Many aspects of cellular physiology remain unstudied in somatic stem cells, for example, there are almost no data on protein synthesis in any somatic stem cell. Here we set out to compare protein synthesis in haematopoietic stem cells (HSCs) and restricted haematopoietic progenitors. We found that the amount of protein synthesized per hour in HSCs in vivo was lower than in most other haematopoietic cells, even if...

Topics

Animals
Cell Proliferation
Cell Transformation, Neoplastic
Female
Flow Cytometry
Genetic Complementation Test
Hematopoietic Stem Cells
Homeostasis
Kinetics
Leukemia
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

PTEN Phosphohydrolase

Proteasome Endopeptidase Complex

Protein Biosynthesis

Puromycin

Ribosomal Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24670665
DOI: 10.1038/nature13035
PMCID: PMC4015626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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