Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal

31 May 2022

Abstract excerpt

Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell function, little is understood of the preventive machinery present in human HSCs that may serve to resist their activation and promote HSC self-renewal. We demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35639948
DOI: 10.1182/blood.2021014698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewalPMID 35639948Read ↗

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stressSemantic proximity Read ↗

Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-RenewalSemantic proximity Read ↗

Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem CellsSemantic proximity Read ↗

Defective ribosome assembly impairs leukemia stem cell function in a murine model of acute myeloid leukemiaSemantic proximity Read ↗

Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo modelsSemantic proximity Read ↗

EIF3H Sustains Translational Programs Essential for Proliferation in Human Primed PluripotencySemantic proximity Read ↗

p53 induces transcriptional and translational programs to suppress cell proliferation and growthSemantic proximity Read ↗

Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cellsSemantic proximity Read ↗

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycleSemantic proximity Read ↗

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cellsSemantic proximity Read ↗

TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fateSemantic proximity Read ↗

Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.