Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

1 Dec 2011

Abstract excerpt

RUNX1 encodes a DNA binding subunit of the core-binding transcription factors and is frequently mutated in acute leukemia, therapy-related leukemia, myelodysplastic syndrome, and chronic myelomonocytic leukemia. Mutations in RUNX1 are thought to confer upon hematopoietic stem cells (HSCs) a pre-leukemic state, but the fundamental properties of Runx1 deficient pre-leukemic HSCs are not well defined. Here we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22145044
DOI: 10.1371/journal.pone.0028430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem CellsPMID 22145044Read ↗

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitorsSemantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

Role of RUNX1 in hematological malignanciesSemantic proximity Read ↗

AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult HematopoiesisSemantic proximity Read ↗

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactionsSemantic proximity Read ↗

Normal and transforming functions of RUNX1: A perspectiveSemantic proximity Read ↗

Runx1/AML-1 Ranks as a Master Regulator of Adult HematopoiesisSemantic proximity Read ↗

Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia.Semantic proximity Read ↗

RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLsSemantic proximity Read ↗

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Semantic proximity Read ↗

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.Semantic proximity Read ↗

The Biology of Hematopoietic Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.