Article
Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence.
The Journal of experimental medicine - 9 Feb 2015
Nakagawa Masahiro Marshall, Thummar Keyur, Mandelbaum Jonathan, Pasqualucci Laura, Rathinam Chozha Vendan
Abstract excerpt
A balance between quiescence and proliferation is critical for proper maintenance of the hematopoietic stem cell (HSC) pool. Although a lot is known about hematopoiesis, molecular mechanisms that control HSC quiescence remain largely unknown. The ubiquitin-editing enzyme A20 functions as a central regulator of inflammation and adaptive immunity. Here, we show that a deficiency of A20 in the hematopoietic system...
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