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IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance

27 Oct 2023

Abstract excerpt

Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood. We investigated the role of interferon regulatory factor 1 (IRF1), a...

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Share to Cytokine Signaling Pathways and Interactions
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PMID: 37889967
DOI: 10.1126/sciadv.adg5391

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