Article
Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
Cell stem cell - 5 Oct 2017
Kleppe Maria, Spitzer Matthew H, Li Sheng, Hill Corinne E, Dong Lauren, Papalexi Efthymia, De Groote Sofie, Bowman Robert L, Keller Matthew, Koppikar Priya, Rapaport Franck T, Teruya-Feldstein Julie, Gandara Jorge, Mason Christopher E, Nolan Garry P, Levine Ross L
Abstract excerpt
JAK1 is a critical effector of pro-inflammatory cytokine signaling and plays important roles in immune function, while abnormal JAK1 activity has been linked to immunological and neoplastic diseases. Specific functions of JAK1 in the context of hematopoiesis, and specifically within hematopoietic stem cells (HSCs), have not clearly been delineated. Here, we show that conditional Jak1 loss in HSCs reduces their...
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