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Article

Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.

Cell stem cell - 2 Jul 2015

Yamashita Masayuki, Nitta Eriko, Suda Toshio

Abstract excerpt

Quiescent hematopoietic stem cells (HSCs) are prone to mutagenesis, and accumulation of mutations can result in hematological malignancies. The mechanisms through which HSCs prevent such detrimental accumulation, however, are unclear. Here, we show that Aspp1 coordinates with p53 to maintain the genomic integrity of the HSC pool. Aspp1 is preferentially expressed in HSCs and restricts HSC pool size by attenuating...

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Identifiers

PMID: 26119234
DOI: 10.1016/j.stem.2015.05.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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