Article

Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in <i>C. elegans</i>

2026-03-20

Abstract excerpt

Tau protein, the primary component in neurofibrillary tangles characteristic of Alzheimer’s Disease and related dementia disorders, normally regulates microtubule growth and stability. While tau dysfunction contributes to the progression of tauopathies, the role of microtubules in disease has remained unclear. Through forward genetic screening in Caenorhabditis elegans tauopathy models, we found multiple tubulin...

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Literature Corpus work: d452379f-0939-516d-8c9f-af58b58244be
DOI: 10.64898/2026.03.18.712642

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