Article

Distinct effects of tubulin isotype mutations on neurite growth in <i>Caenorhabditis elegans</i>

2017-04-26

Abstract excerpt

Tubulins, the building block of microtubules (MTs), play a critical role in both supporting and regulating neurite growth. Eukaryotic genomes contain multiple tubulin isotypes, and their missense mutations cause a range of neurodevelopmental defects. Using the C. elegans touch receptor neurons, we analyzed the effects of 67 tubulin missense mutations on neurite growth. Three types of mutations emerged: 1) loss-of...

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Literature Corpus work: 30f4a5d4-98e5-541c-94e9-5d073f193b17
DOI: 10.1101/131326

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