Article

Context-dependent toxicity of human Tau isoforms in a <i>Drosophila</i> tauopathy model

2026-03-23

Abstract excerpt

Tauopathies are characterised by progressive deterioration of brain regions due to abnormal accumulation of the microtubule-associated protein tau (MAPT). Alternative splicing of MAPT pre-mRNA results in six tau isoforms, which are classified into two groups depending on the number of microtubule-binding domain repeats (3R vs 4R). Although many tauopathies are 3R or 4R-specific, the relative contributions of indiv...

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Literature Corpus work: c90549c3-16a0-5890-8e85-dafdc5f1c95e
DOI: 10.64898/2026.03.20.713147

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